@Mike_Black This sounds strange! My guess is, if the affected interfaces are ETH and Wi-Fi WAN, then it could be related to the PrimeCare validation/update… However, if a reboot restores these interfaces then it should be something else… 
Can you submit a ticket for our team to take a closer look at it?
Please help to provide:
- The device S/N for device verification
- Enable Remote Assistance or download a Diagnostic Report
- Quote this thread so the support team member is aware of the case background