You can use the Amazon Web Servers (AWS is officially supported by Peplink) or another suitable cloud based platform such as Google Cloud Servers (these are not officially support by Peplink). By using the major hosting companies like AWS, then you have choices as to where you can host the server, latency will be an issue from one side of the world to the other only on timing critical applications such as VoIP and live video conferencing, AWS (as do other major hosting providers) have extensive fibre rings and redundancy around the world.
Something you will have to consider in where you host due the the local government regulations, for example most Australian government organisations can not host with google cloud as the data is not stored within the country, so they have to use AWS or another locally operating provider. Also if you are a US based business then you have to consider your data export laws, hosting a system outside of your country could contravene some of the US data export laws depending on your type of business.
There are several here in the forum with successful instances running of the FusionHub SpeedFusion, you can ask the Peplink team to put you in touch directly with a suitable partner to help get you setup and running with ongoing support. I suggest you seek someone locally to work with you, myself I’m based in Australia.
Happy to Help,